DPI mass Covid-19 screening system

DPI mass Covid-19 screening system

 

Where it can be used for maximum impact.

For the rapid detection of Covid-19 infection in the following example areas.

  • Carers
  • Care Homes
  • Swab Covid testing sites
  • All border areas such as airports and transport routes.
  • Sea crossing ports
  • Rail stations
  • Underground
  • Bus stations
  • Universities
  • Conferences
  • Schools
  • Concerts
  • Shopping Malls

Anywhere there are or is a flow of people.

 

Advantages

Before we go into details of the DPI testing methods, we should look at why it should be considered.

The current Covid testing methods are in effect two fold,

  • Either show the patient has had Covid and has antibodies present in the blood.
  • The infection has reached a level that is can be detected by DNA or Nasal (swab test)

From what is known currently, there is a gap between infection and detection.

Due to this unknown time, enforced self-isolation which is causing staff shortages in many areas including hospital and industry.

The DPI is not an antibody or DNA test, it does not require skilled laboratory staff to dedicate time and effort to obtain the results.

The DPI test is a unique approach to analysing the various blood cells.

The DPI requires a small amount of blood, from a pin prick, the same as insulin, to be placed on a glass microscope slide. In simple terms, great details is described below, the red blood cells have a uniform shape for all humans, the laser detection device recognises this normal red blood cell shape. When a virus, and in this case the AI is programmed to detect the Covid-19, attaches itself to the red blood cells, it caused the surface of the cell to deform, the laser detection device recognises this deformation.

Description

What is DPI Covid-19 screening?

Rapid Laserbased DPI (Diffractive Phase Interferometry) technique for Covid-19, based on optical-phase modulation, can give a signature of infection within a few seconds. It is robust and a novel and efficient optical way to interrogate the morphological change in the blood of mass population in a ultrafast time scale. The process is known as mass screening for the purpose of identifying viral infection in the blood cells.

 

Why is this so different to the current methods of Covid-19 testing.

The DPI test is rapid, easy to use, mobile and 95% accurate.

The DPI test show the infection before any signs are showing with the patient, this means that the infection can be found before at any time, this includes the current “unknown” time where we currently have to wait to see if we get ill in the 10 days of isolation.

The DPI test can be done daily, it is quick and easy, reducing the lost time of self isolation, removing the waiting period, removing the requirement for intense laboratory time and expense.

The DPI test give the piece of mind and allows lives to begin to move towards a normal life.

This is a screening process, to detect the presence of the infection. Where the device show an abnormal cell deformation, that is not recognised by the AI, a swab test should be the next action.

It should also be noted that there are a range of other factors that can make the red cell deform, to account for this, the device uses a central remote database and AI to allow continuous updates as new results of the effect of different combinations of drugs show a deformation pattern.

 

Who can operate, skill levels required?

Training is not a technical issue, anybody with first aid experience can be trained very quickly.

Anybody who can be trained to take a finger prick for the blood sample.

 

Method:

Real Time Optical probing of sub-micrometer Deformation in the  Blood cells based on Diffractive Phase Interferometry

 

Procedure:

 

Blood Sample was extracted using Finger prick. Extracted blood is sandwiched between microscope cover slips   and then shine the desirable laser light on it. Blood cells with different dimensions and morphology can generate different effective refractive indices and thus provide different phase distribution as Photons travel along random optical paths. BY judiciously modulating the optical phase-front of a laser beam -with relatively small changes of blood cell morphology can significantly change the angular distribution due interference between the scattered and the refracted light causes the anomalous Airy disk diffraction pattern. The measured light scattering in the small- and wide- angle regimes are thus analyzed using DPI post processing computational algorithms that showcase the optical pattern for the detection of SARS-CoV2 Virus. Thus, rigorously analyzing the angle-dependent scattered speckle characteristics in the pattern, we established a functional correlation between the relevant range of   angle through which the light was scattered and the deformed cell structure that would determine if a person is infected or healthy.

 

Interpretation:

 

This assay significantly detects the impact of SARS-CoV2 Virus on blood cells qualitatively. Both positive and negative controls for the tested effect of viral infection showed expected results. Not detected results may not always rule out current or future infection. Please correlate with clinical findings and repeat if necessary. Lower respiratory samples are recommended in severe and progressive disease. Positive result indicates the Blood sample from SARS-CoV2 was detected and the patient is infected. Negative result indicates SARS-Cov2 Virus not present in specimens above the limit of detection.

Related Product
Face Masks

 

Advantages

Before we go into details of the DPI testing methods, we should look at why it should be considered.

The current Covid testing methods are in effect two fold,

  • Either show the patient has had Covid and has antibodies present in the blood.
  • The infection has reached a level that is can be detected by DNA or Nasal (swab test)

From what is known currently, there is a gap between infection and detection.

Due to this unknown time, enforced self-isolation which is causing staff shortages in many areas including hospital and industry.

The DPI is not an antibody or DNA test, it does not require skilled laboratory staff to dedicate time and effort to obtain the results.

The DPI test is a unique approach to analysing the various blood cells.

The DPI requires a small amount of blood, from a pin prick, the same as insulin, to be placed on a glass microscope slide. In simple terms, great details is described below, the red blood cells have a uniform shape for all humans, the laser detection device recognises this normal red blood cell shape. When a virus, and in this case the AI is programmed to detect the Covid-19, attaches itself to the red blood cells, it caused the surface of the cell to deform, the laser detection device recognizes this deformation.

How to use it

  • he device pictured above is the current modelOperation is simple.
    • Take blood sample from pinprick onto glass slide.
    • Insert slide into top of the device.
    • Begin to process.
    • See the screen image of located the matrix of blood cell

     

    Process time is very low, single digit minutes, this will depend on the cloud connectivity.AI, connected to the cloud will detect and inform of any Covid presence.

About the inventor


Dr. Pramod Kumar heads the research team at QuantLase Lab. His research interests are in the field of ultrafast non-linear photonics covering various fundamental and applicative aspects, in particular the understanding, control and utilization of ultrashort pulse to probe spatio-temporal complex non-linear dynamical behaviour determining the performance of non-linear photonics devices like Photonic Integrated Circuit on the chip scale, diode laser with ultra-short laser pulse injection, optical parametric oscillators, delay-coupled diode lasers system, and nanostructures of semiconductors. Dr. Kumar’s focus is on the study and coherent manipulation of light through photonic structures. Moreover, he has been working on tailoring a non-deterministic white chaotic entropy source based on Optical Perturbative Interferometry for the QKD applications.